Usage, warnings, side effects, and community information for the prescription drug hizentra. Assemble supplies gather the hizentra vials, disposable supplies not provided with hizentra, and other items infusion pump, sharps or other container, patients treatment diarylog book needed for the infusion. Immunoglobulin therapy, also known as normal human immunoglobulin nhig, is the use of a mixture of antibodies immunoglobulins to treat a number of health conditions. Clean surface thoroughly clean a flat surface using an alcohol wipe. Start hizentra 1 or 2 weeks after the last igiv infusion or 1 week after the last weekly igsc infusion. Thrombosis can occur in patients without any known risk factors. Jul 26, 2018 during pregnancy hizentra should be administered only if prescribed. He gets weekly infusions that is derived from plasma donations. The only difference is that the fda package insert for hizentra recommends a dosage of 153% of the patients previous ivig dosage, so you should be getting more grams of hizentra than you were on ivig. I have been selfinfusing hizentra every 2 weeks for 6 months, and find the procedure quite easy to do now that i have been trained by a nurse. Before you carry out the hizentra injection, check to ascertain that the blending pump needle is not in the vein. To learn more about hizentra resources for patients, call igiqcsl behrings ig resource hotlineat 1877355igiq 18773554447 to watch the hizentra video infusion guide, or for more information, visit us online at. Email password if you have forgotten your password click here.
Hizentra, immune globulin subcutaneous human, 20% liquid. Patient resources hizentra immune globulin subcutaneous. The same value can be found in keeping track of your intravenous. Jan 22, 2020 assemble supplies gather the hizentra vials, disposable supplies not provided with hizentra, and other items infusion pump, sharps or other container, patients treatment diarylog book needed for the infusion. It contains the antibodies to help your body protect itself against infection from various diseases. Hizentra is contraindicated in patients with a history of anaphylactic or severe systemic reaction to human immune globulin ig or components of hizentra eg, polysorbate 80, as well as in patients with immunoglobulin a deficiency with antibodies against iga and a history of hypersensitivity.
Protect from freezing refrigerate between 36 and 46 degrees f xembify. Usually, the company or brand name is listed on the label of the bottle or bag that the ivig comes in. Hizentra gives you proven protection with convenient dosing to best fit your lifestyle and preference. As patients are infusing liquid under the skin in each infusion site, puffiness or swelling where the drug is infused. My 8 year old son has an immune disease and his body cant fight infections. Hizentra complete drug information, side effects and. Before starting the infusion, make sure no blood is flowing into the infusion tube. Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. Hizentra information, side effects, warnings and recalls. It actually happened after i had finished the infusion and removed all the needles i have four. Hizentra vial side effects by likelihood and severity webmd. Check with payer for hizentra coverage aapc knowledge center. You may not be able to use immune globulin subcutaneous if you have ever had an allergic reaction to polysorbate 80, or if you have a condition called hyperprolinemia high level of a certain amino acid in the blood. Gamunexc immune globulin injection human, 10% caprylatechromatography purified is approved to treat primary.
I do want to acknowledge after the first infusion after four days of experiencing the same side effects i did start to feel better and then the next three weeks were the best ive felt in about 10 years. L left h hips u upper leg legthigh scig brand name. In short, hizentra is a type of human immunoglobulin mostly igg i will get into the types in my immunology 101 video to come. Selected from data included with permission and ed by first databank, inc.
Never use this drug if it has particles in it or if it has changed colors. Jun 05, 2019 please see the myhizentra infusion manager app information below. The vast majority of patients are still on iv and the costs per gram are about the same. After my second infusion the next day i came down with bronchitis and it took a full month for me to recover. Hizentra, the first and only readytouse 20% solution for subcutaneous infusion scig, is a weekly or biweekly therapy that can be safely selfadministered. The majority of reports of serotonin syndrome related to 5ht 3 receptor antagonist use occurred in a postanesthesia care unit or an infusion center. It is actively marketed as a weekly subcutaneous infusion. I am an older lady and started hizentra infusions a month ago. Patient discharge instructions for hizentra local site reactions can be expected during the infusion and diminish as the drug is absorbed over the following 12 days. Assemble supplies gather the hizentra vials, disposable supplies not provided with hizentra, and other items infusion pump, sharps or other container, patients treatment diary log book needed for the infusion. Specialty infusion offers treatment for amyotrophic lateral sclerosis als with edaravone radicava, and the following multiple sclerosis ms therapies. Weekly infusions were well tolerated throughout a treatment period of up to 3 years.
Infusion logbook keep your infusion information together and organized. In todays digital age there are many choices for keeping a treatment log. Hizentra also referred to as immune globulin is made of uncontaminated solution prepared from human plasma. Instead, you can selfadminister by infusing just under the skin, not into your veins, after receiving training from your doctor. Immunoglobulin therapy is used in a variety of conditions, many of which involve decreased or abolished antibody production capabilities, which range from a complete absence of multiple types of antibodies, to igg subclass deficiencies usually involving igg2 or igg3, to other disorders in which antibodies are within a normal quantitative range, but lacking in quality unable. Csl behring does not recommend specific infusion pumps. Hizentra place patient label here or clearly print patient information.
Serotonin syndrome occurring with overdose of ondansetron hydrochloride alone has also been reported. Remove the peeloff portion of the label from the used vial. The treatment used include the brand name, the expiration date, the lot number, and the number of units administered the reason for the infusion for example. To assess the safety and tolerability of higher infusion rates applied via the manual push and pumpassisted administration, 49 pid subjects aged 2 to 75 years were enrolled in an openlabel, multicentre, parallelarm, nonrandomised phase iv hilo hizentra label optimization study and treated with hizentra for at least 12 weeks 11 paediatric. Medicare coverage and pricing details for hizentra. Hizentra, supplied in singleuse vials of 5 ml, 10 ml, or 20 ml, is an igsc 20 percent liquid indicated for the treatment of primary immunodeficiency pigenerally reported with an icd9cm code under category 279 disorders involving the immune mechanism. It comprises of antibodies to assist your body fight against a range of infections coming from different diseases. Adjust the dose based on clinical response and serum igg trough levels see dose adjustment. Local reactions were the most frequent aes observed, with injectionsite reactions i. Feb 21, 2020 to assess the safety and tolerability of higher infusion rates applied via the manual push and pumpassisted administration, 49 pid subjects aged 2 to 75 years were enrolled in an openlabel, multicentre, parallelarm, nonrandomised phase iv hilo hizentra label optimization study and treated with hizentra for at least 12 weeks 11 paediatric.
Please see the myhizentra infusion manager app information below. Hizentra 200 mgml solution for subcutaneous injection in pre. In the clinical study after transitioning from igiv to hizentra, a dose of 0. How to keep an infusion log immune deficiency foundation.
Start hizentra 1 week after the last igiv or igsc infusion. Read the patient information leaflet provided by your pharmacist before you start using immune globulin and each time you get a refill. Immune globulin is also used to treat chronic inflammatory demyelinating polyneuropathy an autoimmune disorder in which the immune system attacks the nerves, causing muscle weakness and numbness. If your patients primary payer drug claim is billed under medical benefits, you can request hizentra immune globulin subcutaneous human, 20% liquid copay assistance using this portal. Hizentra injection which is shot under the skin is utilized in effective treatment of primary immunodeficiency pi which includes but not restricted to common. As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. Hizentra immune globulin subcutaneous human 20% liquid is an immune globulin indicated for the treatment of primary immunodeficiency in adults and pediatric patients 2 years of age and older. Infusion therapy can be an important part of treatment for neurological conditions affecting the brain, spinal cord, andor nervous system. The high concentration 20% might allow shorter infusion times due to smaller infusion volumes, with potential improvement in the convenience of scig therapy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hizentra is a subcutaneous infusion therapy, which means an iv is not involved. Longterm efficacy, safety, and tolerability of hizentra for treatment.
Feb 21, 2020 hizentra 200 mgml solution for subcutaneous injection in prefilled syringe human normal immunoglobulin scig s ub c utaneous i mmuno g lobulin read all of this leaflet carefully before you start using this medicine, because it contains important information for you. Hizentra immune globulin subcutaneous human injection. Section a prescription order for hizentra section b patient information section d section c treatment settings patient insurance information patients innetwork provider. The use of gloves when preparing and administering hizentra is optional.
What are the possible or reasonably likely side effects of cuvitru. Included are all aes and those considered temporally associated with the hizentra infusion, i. This includes any possible side effects not listed in the package leaflet. Apr 01, 2020 gather the hizentra prefilled syringes or vials, all supplies, and infusion log book. Csl behring, berne, switzerland is the first, readytouse 20% liquid preparation of human igg specifically formulated for subcutaneous infusions. Our hizentra immune globulin subcutaneous human 20% liquid side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Thrombosis may occur with immune globulin products, including hizentra. Learn more about medicare prescription drug plans and savings with goodrx. Gather the hizentra prefilled syringes or vials, all supplies, and infusion log book. Csl behring immune globulin subcutaneous human igsc, 20%. Feb 18, 2020 assemble supplies gather the hizentra vials, disposable supplies not provided with hizentra, and other items infusion pump, sharps or other container, patients treatment diarylog book needed for the infusion.
Administration infusion sites 1 to 4 injection sites simultaneously, with at least 2 inches between sites. Hizentra medicare coverage and copay details goodrx. Things have been going pretty well but last night for the first time i had an intense burning reaction to one of my needle sites. The myhizentra infusion manager application reminds patients when their next infusion is due, and helps them record details of each infusion for easier tracking. The brand refers to either the companys name that makes the ivig or the brand name that they use for their specific immune globulin. Immune globulin subcutaneous for injection under the skin is used to treat primary immunodeficiency diseases.
J1559 hcpcs code hizentra injection hcpcs registry. Follow your doctors instructions on how to use the infusion pump. Infusion administration tubing subcutaneous needle or catheter sets syringes transfer device or needles gauze and tape, or transparent dressing infusion pump sharps container alcohol wipes antiseptic skin preps. Initiate therapy with hizentra 1 week after the last igiv infusion. Hizentra 200 mgml solution for subcutaneous injection. Csl behring immune globulin subcutaneous human igsc. Hizentra fda prescribing information, side effects and uses. Hizentra subcutaneous must not be injected into a vein. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Jan 30, 2016 in short, hizentra is a type of human immunoglobulin mostly igg i will get into the types in my immunology 101 video to come. Learn about hizentra from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions.
Specialty rx infusion treatments prestige infusions. Aug 03, 2017 do not mix hizentra with other drugs in one infusion. Place this label in your treatment diary or log book. Hizentra is manufactured by csl behring ag and distributed by csl behring llc.
Hizentra is an immune globulin subcutaneous human igsc. Subcutaneous immunoglobulin replacement therapy with hizentra. Apr 07, 2016 my 6 yr old daughter johnelyi has been getting hizentra since she was 4 12 yrs old she is now 6 and its helping her a little not to get sick as much but sh. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Thromboembolism is known to be associated with immune globulin therapy, regardless of the route of administration. My 6 yr old daughter johnelyi has been getting hizentra since she was 4 12 yrs old she is now 6 and its helping her a little not to get sick as much but sh. Hizentra provides effective protection against infection by maintaining a steady and normal level of immunoglobulin in the body. Subcutaneous immune globulin home infusion log pickup transfusion medicine location. Hizentra infusion immediately and institute appropriate treatment. Immune globulin intramuscular route, intravenous route. Infusion volume first infusion, up to 15 ml per site. If any of the following problems occur after starting cuvitru, stop the infusion immediately and contact your hcp or call emergency services.
Hizentra immune globulin is a sterilized solution made from human plasma. Site legend r right a abdomen transfusion medicine phone. If you get any side effects, talk to your doctor, pharmacist or nurse. Hizentra is an immune globulin subcutaneous human igsc, 20% liquid indicated for the treatment of the following conditions.